Can Darwin Help Your Doctor?

first_imgAre you sick? Should you rely on Darwinism or Science?by Jerry Bergman, PhDUnder the headline “Darwin can help your doctor,” a press release from the University of Groningen claimed that “Evolution and ecology inspire clinical research in infections and antimicrobial resistance”[1]. The editors explain: “Taking an evolutionary view can inspire new ideas in clinical microbiology. For example, evolutionary studies can reveal why some antimicrobial dosing regimens are better than others in preventing the development of drug resistance.”As I read the review, it soon became apparent that the word evolution was tacked onto the report for no good reason except to give obeisance to Darwinism. The approach described in the report had nothing to do with Darwinism but was rather an example of the classic empirical experimental approach. This approach requires scientists to evaluate the proposed “antimicrobial dosing regimens” on patients and then study the outcome. For example, a sample of affected patients would be randomized into 5 treatment groups of 20 patients each, then the outcome of each group is compared. If statistical differences are found at the alpha 0.05 level or better (such as alpha 0.01) to insure the difference between the two is very unlikely due to chance, this lends evidence to the conclusion that the protocol found most effective is actually, as a whole, more effective. The report then added:Looking at microbial communities, rather than just the pathogenic micro-organisms, can also lead to new insights. That is why clinicians, bioinformaticians analysing pathogens and evolutionary biologists should all work together. These are the conclusions of a diverse group of scientists led by University of Groningen microbiologist Marjon de Vos, in a short review published by The Lancet Infectious Diseases on 30 April.[2]Again, this is an example of an obvious truism. Of course, “clinicians, bioinformaticians analysing pathogens and evolutionary biologists should all work together.” I have to wonder what evolutionary biologists could possibly contribute. MicrobiologistDe Vos studies urinary tract infections. She realized that a lot could be gained by collaborating with different specialists … For example, …  bacteria involved communicate with each other and can form a stable ecosystem, which affects their susceptibility to antibiotics.’ This realization led to an interdisciplinary workshop in 2017, which in turn resulted in the review paper now published in The Lancet Infectious Diseases.[3]Still no answer as what this research has to do with evolution. So I read on.The consensus can be wrong, and has been wrong numerous times, when it comes to evoluition.The article then discussed cystic fibrosisThe review mentioned bioinformatics, which is an analysis of “the vast amount of genetic data collected on infectious diseases.” This also has nothing to do with evolution unless one is searching for long-term, millions of years, evolutionary trends. In this case, the bioinformatics technique is a fishing expedition looking for trends in gene expression patterns that may relate to the medical condition of concern. The doctors explain that cyclic antibiotic treatments in cystic fibrosis patients are used to treat chronic lung infections which are common in this condition. To minimize the development of drug resistance, treatment alternates with two different drugs.[4] If the pathogens become resistant to one drug, ideally, the other will be effective. Obviously, this approach could result in multi-drug resistance.This is the claim I was expecting, which has nothing to do with evolution. I will cover the most common claim, that is antibiotic resistance due to mutations which create bacteria incorrectly termed “superbugs.”How do bacteria develop resistance to antibiotics?Although bacteria can become resistant due to mutations, all these mutations studied so far are either loss mutations, or damage-to-gene-expression mutations that damage the system that speeds up the removal of, or the inactivation of, antibiotics. None of these effects are the result of new cellular innovations, but are caused merely by damaging something in the bacteria.One type of mutation can alter the shape of the antibiotic binding site. The antibiotic works by fitting into the antibiotic binding site and, like a lock and key, if the keyhole is damaged, the key will no longer fit into the lock. Likewise, if the antibiotic binding site is distorted as a result of damage caused by mutations, the antibiotic will no longer fit into the antibiotic binding site, protecting the bacteria from the antibiotic.A side effect is the mutation can degrade or destroy the function for which the bacteria binding site was designed. For example, a neutral mutation in one amino acid that prevents the required antibody-enzyme interaction alters the binding site on the 4-quinolone antibiotic which disables the DNA gyrase enzyme in bacteria. The gyrase enzyme is an essential bacterial enzyme that catalyzes the ATP-dependent negative super-coiling of double-stranded closed-circular DNA. It reduces the twisting strain occurring while double-stranded DNA is being unwound by elongating RNA-polymerase.The classic example of mutations in the antibiotic mechanism which causes the bacteria to become immune to the antibiotic is ribosome point mutations that renders streptomycin and other mycin antibiotics ineffective.[5]  Mycin antibiotics function by attaching to specific receptor sites on the bacteria’s ribosomes which are required to produce protein to keep the bacteria alive. The result is this antibiotic action interferes with the bacteria protein-manufacturing process.  The proteins the bacteria produce are, as a result of the mutation, either non-functional, or are not even produced. The result is the bacteria cannot grow and divide, or propagate.Bacterial mutations cause the bacteria to become streptomycin-resistant if the ribosome site, where the streptomycin attaches, is altered by mutations. As a result, the streptomycin no longer can bind on the host ribosome, and therefore it no longer can interfere with the ribosomal function of producing protein. Mutation-caused changes that enable the bacteria to become mycin-resistant can occur in several different locations on the ribosome.[6]Mammalian ribosomes do not contain the specific site where myosin drugs attach, and for this reason the drug does not interfere with mammal ribosome function. Consequently, mycin drugs adversely affect bacterial growth without harming the host. Because fundamental differences exist between prokaryotic (bacterial) and eukaryotic ribosomes, these variations often are exploited in order to produce antibiotics to kill bacteria without harming the host. Actually, many antibiotics used are produced by fungi or other bacteria to protect them from enemy bacteria. Humans obtain them to protect them from the same pathogenic bacteria.Another example of a mutation-caused resistance is, in Mycobacterium tuberculosis bacteria, an enzyme in the bacteria that changes the antibiotic called isoniazid into its active form that kills the bacteria. If a mutation damages the enzyme that converts the antibiotic into its active form, the antibiotic remains in its inactive and harmless conformation. As a result, this mutation confers antibiotic resistance to the mutant bacteria.[7] The mutation that damages the enzyme which prevents the antibiotic from killing the bacteria also cripples the bacteria, an effect called the fitness cost.When bacteria become resistant to antibiotics as a result of mutations, all the mutations studied so far are either loss mutations, or gene-expression mutations that result in speeding up the systems that removes or inactivates antibiotics. None are the result of new cellular innovations but are caused merely by altering the regulation control.all the mutations studied so far are either loss mutations, or gene-expression mutationsEvolution by retreatIn short, this brief discussion illustrates the fact that all known examples of antibiotic resistance are due to inbuilt systems designed to achieve symbiosis, or damage to some system in the host or pathogen that prevents it from properly defending itself. In short, so-called super bacteria are actually damaged bacteria that have an advantage in an environment loaded with antibiotics, such as in a hospital.Conversely, mutations that add new systems, such as a new regulatory system, energy-generating system, or transport system, have never been documented. Mutations increasing certain enzyme affinity may be beneficial, but often occur rapidly, indicating that design is involved. For example, mutations effecting hemoglobin-oxygen affinity help the host to acclimatize to a high altitude, but the same mutation can also cause polycythemia. This response is not evolution, but rather designed adaptation.Mutations that alter a protein which results in antibiotic resistance are also likely to weaken the organism. Mutations that both confer resistance, and allow the bacteria to survive, do not improve the bacteria fitness in its normal environment. The bacteria actually render them less able to survive in an antibiotic-free environment.[8]  Thus, when the bacteria becomes resistant to a drug, it is likely to become less fit in other ways.[9]  This is called the cost of resistance, or the fitness cost.[10] Often the cost is very high and the mutation renders the resistant stain poorly able to survive in a non-antibiotic environment.[11]The last claim covered in the The Lancet Infectious Diseases article was resistance plasmids. Resistance plasmids are small circular DNA that confers resistance to bacteria that can easily be exchanged between bacteria. The Lancet review admits “we still don’t know how changes in genes lead to the different characteristics of these pathogens. We need experiments by evolutionary biologists in order to understand the link between the genotype, the DNA sequence and the phenotype – for instance, the level of resistance.”[12]Empty boastsThe 11-page Lancet article contained the word evolution 103 times and, after analyzing each example, the same problem was found as I have documented in this paper.[13] Of interest is the article’s list of examples of the successes of microbial evolutionary medicine, including the exploitation of the alleged bacterial evolutionary molecular clock to trace transmission events over time in hospitals and continents in spite of the fact that the molecular clock has been a dismal failure, at least for long periods of time.[14][1] “Darwin can help your doctor.” Science Daily. 30 April 2019. https://www.sciencedaily.com/releases/2019/04/190430103424.htm.[2] “Darwin can help your doctor.” Science Daily. 30 April 2019. https://www.sciencedaily.com/releases/2019/04/190430103424.htm.[3]  Sandra B Andersen, et al. Microbial evolutionary medicine: from theory to clinical practice. The Lancet Infectious Diseases, 2019 DOI: 10.1016/S1473-3099(19)30045-3[4] Sandra B Andersen, et al. Microbial evolutionary medicine: from theory to clinical practice. The Lancet Infectious Diseases, 2019 DOI: 10.1016/S1473-3099(19)30045-3[5] Davies, A. P., et al., 2000. “Comparison of Fitness of Two Isolates of Mycobacterium tuberculosis, One of which had developed Multi-Drug Resistance during the Course of Treatment.”  Journal of Infection, 41(2):184-187, Sept.; Davies, J. and M. Nomura,  1972. “The Genetics of Bacterial Ribosomes.”  Annual Review of Genetics,  6:203-234.[6] Didier, E. S., D. C. Bertucci, and L. Leblanc,  1999. “Inhibition of Microsporidia Growth in vitro.”  Abstracts of the General Meeting American Society Microbiology,  99:11[7] Wieland, Carl, 1994. “Antibiotic Resistance in Bacteria.”  Cen Tech J., 8(1):5-6, p. 5.[8] Wieland, 1994, p. 6.[9]Spetner, Lee, 1997. Not by Chance. Brooklyn, NY: The Judaica Press, p. 144.[10]Lenski, Richard E., 2002. “Cost of Resistance” in Encyclopedia of Evolution.  Volume 2, pp. 1008-1010.  New York, NY: Oxford University Press.  Mark Pagel (editor), p. 1009.[11]Baquero, Fernando,  2002. “Antibiotic Resistance:  Origins, Mechanisms, and Extent of Resistance” in Encyclopedia of Evolution.  Volume 1, pp. 50-54.  New York, NY: Oxford University Press.  Mark Pagel (editor). p. 51.[12] “Darwin can help your doctor.” Science Daily, 30 April 2019. https://www.sciencedaily.com/releases/2019/04/190430103424.htm.[13] Andersen, Sandra B., 2019. Evolutionary medicine: from theory to clinical practice. The Lancet Infectious Diseases, online 30 April 2019. https://www.thelancet.com/action/showPdf?pii=S1473-3099%2819%2930045-3.[14] Jeffrey Tomkins and Jerry Bergman, 2015. “Evolutionary Molecular Genetic Clocks–A Perpetual Exercise in Futility and Failure.” Journal of Creation, 29(2):26-35. Dr. Jerry Bergman has taught biology, genetics, chemistry, biochemistry, anthropology, geology, and microbiology at several colleges and universities including for over 40 years at Bowling Green State University, Medical College of Ohio where he was a research associate in experimental pathology, and The University of Toledo. He is a graduate of the Medical College of Ohio, Wayne State University in Detroit, the University of Toledo, and Bowling Green State University. He has over 1,300 publications in 12 languages and 40 books and monographs. His books and textbooks that include chapters that he authored, are in over 1,500 college libraries in 27 countries. So far over 80,000 copies of the 40 books and monographs that he has authored or co-authored are in print. For more articles by Dr Bergman, see his Author Profile.(Visited 301 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

South Africa’s population breaks 54-million

first_img1 August 2014Life expectancy in South Africa continues to rise as the country’s population breaks the 54-million mark, Statistics South Africa reported on Thursday.Releasing its latest mid-year population estimates report in Pretoria, Stats SA said the country’s population grew by an estimated 1.58% between July 2013 and July 2014, increasing by about 844 000 people to stand at just over 54-million in total.According to the report, South Africa’s life expectancy at birth now stands at 61 years, having increased from an estimated 52 years in 2005, thanks to a lower infant mortality rate and a decrease in the number of Aids-related deaths in the country.Stats SA said the decline in South Africa’s infant mortality rate – from an estimated 58 infant deaths per 1 000 live births in 2002 to 34 infant deaths per 1 000 live births in 2014 – pointed to an improvement in the general health and living standards of the population.Aids-related deaths, meanwhile, dropped from an estimated 363 910 deaths (51% of all deaths) in 2005 to 171 733 deaths (31% of all deaths) in 2014, as a direct result of the increased rollout of free antiretroviral therapy in the country.According to Stats SA, the overall number of deaths in the country decreased from an estimated 716 083 deaths (15 deaths per 1 000 people) in 2005 to an estimated 551 289 deaths (10 deaths per 1 000 people) in 2014.At the same time, the country’s birth rate has decreased, from 24 births per 1 000 people in 2002 to 22 births per 1 000 people in 2014.Stats SA said the dual transition from high to low birth and death rates had changed the age structure of South Africa’s population, resulting in both a high proportion (30%) of the population under the age of 15, as well as growing proportion of elderly people, with an estimated 4.5-million people aged 60 years or older.SAinfo reporterlast_img read more

Boston Mulls a New Template for Urban Housing

first_img RELATED ARTICLES A Boston startup is proposing a new housing model designed to solve a fundamental problem with urban apartments — they’re too big.The company, Livelight, and architect Tamara Roy developed a model for very small modular apartments that can be racked in steel-framed exoskeletons on small infill lots, expanding housing opportunities for one- and two-person urban households. The project also had the backing of the Boston Society of Architects.Livelight founder Addison Godine said he was approached by the Mayor’s Housing Innovation Lab and asked to design a micro-apartment on wheels. He and Roy, then the incoming president of the Boston Society of Architects, rolled up their sleeves and developed a prototype called the Urban Housing Unit, or uhü, and submitted the design in a competition for development of a city-owned lot in Boston’s Roxbury neighborhood.“Among many initiatives one of their interests was compact living spaces as a potential partial solution to the housing crunch that was happening in Boston,” Godine said of the Innovation Lab in a telephone interview. “There is a great mismatch between the housing stock and the citizenry — 17% of the housing stock in Boston is studio and one-bedrooms but 67% of Boston city residents are one- and two-person households.” Cities Think Small to Ease the Housing CrunchTiny Houses Join the Building CodeBuilders Aren’t Jumping on the Tiny House BandwagonLumber Store Chain Now Offers Tiny Houses Their 385-square-foot prototype, built at a modular factory in Pennsylvania, was parked for its introductory exhibition at City Hall Plaza last August and has since been trucked to eight different sites around Boston. Thousands of people have taken the tour, and sometime this spring, the city is due to decide whether Godine can move forward with a proposal to rack seven units on the Roxbury property and put them on the market.Boston is one of a number of cities looking at very small dwelling units as a way of making affordable housing more available (see “Cities Think Small to Ease the Housing Crunch” in the sidebar below). What comes in the packageThe uhü is 13 feet 10 inches wide, 33 feet long, and 11 feet tall — something like half of a conventional single-wide manufactured home. Including the trailer, it weighs 20,000 pounds.Exterior walls are framed with 2x8s and insulated with R-31 fiberglass batts. Both the floor and the roof are framed with 12-inch I-joists and insulated with fiberglass. (The roof also has a layer of rigid foam insulation.) Godine estimated nominal R-values of 40 in the floor and between 50 and 55 in the roof. Windows are double-pane Marvin Integrity.Cladding for the prototype is a translucent polycarbonate material called Polygal, which allows the uhü to glow at night. If it were ever to be put into production, Godine said, it could have siding more appropriate for an urban property — something like fiber cement.The uhü is heated and cooled with a single-head Mitsubishi Hyper-Heat ductless minisplit with a rated capacity of 18,000 Btu. Godine said the unit is capable of producing heat with outside temperatures as low as -23°F. It also comes with a Nest thermostat, just so residents don’t squander the chance to save energy.The design also includes Intello, a membrane used for airtightness and vapor control. There was, however, no money in the budget for a blower-door test.It cost $85,000, including the trailer, all furniture, and all appliances. Godine would like to see the cost to drop to between $40,000 and $50,000. People needed to see the real thingThe city had been touring neighborhoods to talk about the potential of more compact housing and micro-apartments, Godine said, but more often than not the reaction was a blank stare. Staffers from the Innovation Lab tried marking the outline of a micro-apartment on a gym floor with blue painter’s tape, for example, in order to give prospective tenants an idea of what living in one would be like. It just wasn’t clicking.“It didn’t really communicate what a space could be like,” he said, “so they said what we really want to do is build a real one.”He and Roy were both familiar with little houses. Godine managed the 2011 Solar Decathlon team while a student at Middlebury College, a role that encouraged the study of small, unconventional residential spaces. Later, he worked for a company called Getaway that placed tiny houses in rural settings and rented them to city people. Roy had lived in a 300-square-foot apartment in the Netherlands with her husband and their baby while earning her master’s degree, and has become a widely known advocate for micro-apartments since then. She’s now a principal at Stantec, where her bio says she’s been nicknamed the “mother of the micro-unit.”Once Roy knew she was in line to take over the Boston Society of Architects, she saw an opportunity to promote a favorite theme.“I knew that I had this once-in-a-lifetime chance to put some of the ideas we have for making more efficient smaller units and getting the word out there that they weren’t going to be tenements or old boarding houses,” she said. “We could show it was really a solution that was going to meet the demand that people in smaller household sizes have in Boston.”She lined up a meeting with Godine, and they soon decided to join forces and respond to the request-for-proposal from the city. The pair decided modular made the most sense for the apartment prototype, and they contacted a number of factories before settling on PennKraft Building Systems in Pennsylvania.Once the uhü was delivered, the tours began. What the 3,000 or so visitors saw was a long, boxy structure with a kitchen, a code-compliant bathroom, a sleeping alcove, a living/dining area that could seat six for dinner, and a variety of storage shelves and lockers — all in a package much better insulated and air-sealed than a typical city dwelling.A video narrated by Roy at the Livelight website runs through the basics.According to Godine, only 2% of those who toured the uhü said it wasn’t for them or wouldn’t fit in their particular neighborhoods. Others expressed “some range of bewilderment” about the project but not necessarily a negative view. A number of visitors said they were familiar with the idea of micro-apartments because of television coverage of tiny houses. Reaction ‘mixed’ at neighborhood roll-outGodine’s plan, should he win the city’s OK, would be to stack a total of seven units in a three-story steel rack on the Roxbury lot (see the second to last image below) and put them up for sale. The studios would sell for $149,000 and the two-bedroom units — expanded versions of the prototypical uhü 52 feet long and measuring 621 square feet — would sell for $199,000.The steel rack is what Godine calls pallet rack framing, just as you’d see in Home Depot or any distribution warehouse. “The idea,” he said, “is you can slot in your uhü or whatever, much like boats slot into a marina.”One problem yet to be overcome is the city’s current minimum size requirement for dwellings. Studio apartments must be a minimum of 450 square feet; one-bedrooms must be 625 square feet.“You have to get around that somehow,” Godine said. “My company thinks you shouldn’t have to get around it. You should just be able to build this small because, really, there’s no problem with it.”Another potential problem is public acceptance of a design that’s more contemporary than its surroundings. Godine said the Roxbury proposal recently was the subject of a public presentation in the neighborhood and got a “mixed” reaction.“The question is whether they want this kind of design in their neighborhood at all,” Godine said. “It’s a fairly conservative neighborhood, and this many be rocking the boat with something contemporary looking.”last_img read more

Maybe, Just Maybe, Twitter’s On To Something With Metrics

first_imgFacebook is Becoming Less Personal and More Pro… Now, I hate this change. I think it breaks the very idea of what I loved about Twitter, and I strongly advocate for alternatives that are more supportive of independent developers of new experiences.But what Williams said Monday made me take a longer view for the first time.If Twitter controls its entire information pipeline, it can get more accurate readings of what’s going on in there. Everyone who’s opposed to Twitter’s trajectory knows that this will help the company make a lot of money by better targeting ads.That’s the whole problem; it feels like what’s good for ads is bad for us.But what if there really are “dream metrics” that would make Twitter more meaningful to us, too?No one likes a popularity contest, and that’s what follower counts are. By definition, they’re discouraging to most people. They make some feel insignificant. A more robust metric could create a more nuanced and useful picture of how people succeed or fail on Twitter.Maybe Twitter will find some lasting value in its messages that that can only be captured if it controls the whole service. Maybe that value is a more personally empowering way to use Twitter.Maybe. Speaking Monday, Twitter co-founder and board member Ev Williams described what he’d like the microblog to be when it grows up. Some fear that he wants to merchandise tweets the way Hollywood merchanises movies. But for the first time in months and months, I saw the glimmer of a Twitter that I could learn to love.“The ‘dream’ metric is how many people saw your tweet,” Williams said. What does he mean, exactly? Williams pointed to the follower count as a blunt instrument. It has always been the de facto measurement of how powerful a Twitter poster is, but it doesn’t mean much. Not all followers are equal. Hundreds might be porn bots. Or you might have just 31 followers who lovingly retweet everything you post.So a better measurement of how important you are on Twitter is how many people you reach, not just how many once clicked “Follow.” Reach is how many Twitter feeds your tweet ended up in, whether directly or from a retweet. It’s also how many people viewed your tweet embedded on a site or in a blog post. And those aren’t even all Twitter members!But that’s not all that Williams dreams of measuring. Twitter could also measure the activity generated by your tweets — retweets, favorites, replies — to see how much people care about them.All this stuff would be would be much more useful for figuring out one’s Twitter strength at a glance.Here’s the rub.Twitter is cut from some data when people use third-party Twitter clients like Twitterific and Tweetbot. Those apps add all kinds of ways of interacting with tweets that are built on top of Twitter, not built into it.In August, after promising to do so for a long time, Twitter began to crack down on third-party apps and unofficial ways to display tweets. Twitter isn’t cutting off outside Twitter apps — at least not right away — but itis being much more strict, particularly about displaying tweets. The Dos and Don’ts of Brand Awareness Videos Related Posts Tags:#twitter#web Guide to Performing Bulk Email Verification jon mitchell A Comprehensive Guide to a Content Auditlast_img read more

B2B Customer Experience, 13 Actions Bringing Better Results

first_imgTechnology is always making headway in the business world, entrepreneurs and many business veterans have been incorporating the innovational ways to transcend their rivals.            They say if Content is the king, Customer experience is the queen.  Customer experience purely depends on how you make your customers feel during the interactions. The way you sort your priorities and your business representation needs to excel.Compared to B2C, B2B is more demanding in terms of productivity and thus needs special attention for the providers. And why not, a B2B buyer offers you orders in big volumes. Remember the efforts you put on for insisting a B2C customer to purchase one item. This time, the desired effort magnitude is a thousand times higher.This article illustrates everything you need to know about how you can improve the B2B customer experience with your e-commerce endeavours. But before delving deep, let’s have: A sneak-peak at why customer experience matters in B2BThe B2B decision-makers every time have a vendor selected in mind even before a purchasing group is formed. As a result, the stakeholders offer a fat chance to let a new party in. And, that is the only space you are provided in the process.B2B offers very little room to allow aberrations. You can’t just play around when your prospects are that reserved with their choices. It turns really important to strike the right note in the limited time frame. Above all, their existing vendors have set a threshold with the services and retention offers. Your strategies need to whipsaw the existing filters to initiate the possibilities.Now, here is a pie-chart that explains the ill-effect of serving bad. According to Groove, 82% of customers let go of a company due to bad customer experience in the past.From the sales point of view, the ratio is alarmingly high and needs to be addressed right.The same source also claims that the customers are willing to pay extra, in exchange for a better CX. The clients are ready to spend around 140% more than usual, based upon their past user experience with the company. That being said, a B2B owner can expect their clients to come round again with more revenue. The only condition is if they develop a more Customer-centric approach.Proven Steps To Improve B2B customer experienceB2B business owners can dramatically enhance customer experience and achieve the bottom line gains by utilizing buyers’ familiarity with some common B2C site functions. Above all, they need to make sure that they are saving the clients’ precious time and pitching their best in the nutshell.Being said that, we have jotted down the most tried-and-tested ways that can level up the way customers perceive your business.An interactive ChatBot optimizes the chances of conversionA famous quote says “The first impression is the last impression.” That’s why Chatbots find themselves useful on most websites these days. Keeping the prospects engaged is one way of making the interaction more riveting. Attending the customer can actually take them down the lead funnel quicker. Compared to Email Marketing and cold call attempts, Chatbots are rather dynamic and can fetch their details with much ease.Modern-age Chatbots can make the rate negotiations on your behalf, even when you are off the system. Concise Content that defines your purposeThe businesses are well aware of the market and prefer to research before entering into any deal. While they are in touch with you, they are alongside considering other vendors to get the best product at the best price, they have already explored your websites deep and the surveys that relate to you.You can take this as an advantage; strengthen your contents, let them speak of your motto well aloud, let them define your endeavours and objectives with clarity. All this be done in a well-directed manner.User case studies bridge the gap effectivelyCase studies have played a crucial role in bridging the gap between a customer and the business. It needs a good grip on the buyer’s persona and a clear understanding of your product. The B2B owner can take help of their existing clients, who play the lead character in the plot. Case study portrays main character’s problem and the solution offered by the product.In most cases, the customers find themselves on the character’s shoes thus offering the much-needed connection.With Product Personalisation, customers can have a better choiceWhat if the customer liked the design of your product, but not the colour? What if he denied just because he disfavored the text? There are tools that can save you from losing the ground.Product Personalization allows your customers to have products of their choice. They can select the design and variant on their own. It is now a part of the major State of the art eCommerce websites. With several variants of the same product, the customer has better chances of getting converted.B2B owners can find such applications across all the major e-commerce platforms. Image SourceWith personalized recommendations, make them feel more valuedKeeping in mind that the other side of the B2B model is a procurer, the content needs to be highly personalized for specific customers. Features like product recommendations and customised best-seller lists can give B2B companies the chance to grow personal relations with the buyers.The Sellers can pitch Upselling and Cross-selling strategies to enhance the possibility of closing the deal.Influencing the C-Level decision makerA chain of multiple decision-making layers is one of the major factors that differentiate B2C from B2B. At an average, 6.8 people are involved while making a B2B purchase. The Champion stakeholder among the decision makers plays the lead role. Friendly referrals or impressing the champion can effectively break the obstacles.C-Level decision makers seek concise and focussed interactions. Time is a big constraint at these sessions. The best part- they favour a lasting relationship.Adding a lead score on customer’s growing interestAttaining a lead is not the end of the journey. A lead, if nurtured well can get you bulk orders. Adding lead score for every advancement by the customer can help you classify their status and the chances of them being converted. Most B2B owners pitch further knowledge of services with the rising lead score. Image SourceThe picture above is an example that represents the way, the lead score is offered at every step.Managing Abandoned Cart to remind them of the purchaseB2B prioritises a lot of segments, thus wrapping up for the deal can often take time. On average, more than 60% of the purchases are cancelled during the checkout. It is thus necessary to manage the cart abandonment with utmost priority.Most B2B owners pitch discounts within 15-30 minutes of cart abandonment. As per Salecycle, 28% of the carts are rescued in the process.Data Analytics attracts BuyersThe B2B customer is a marketer, and data is their native language. How easy would it be for the buyer if you lt them keep a track of their orders on the website?With Data Analytics being integrated into the b2b website, the Buyer can view order histories and other related information. These user-specific graphs are highly personalized and offer a special treatment to your buyers. Here is an example of the same: Handshake for B2B.Detailed Data Sheets with important points making the top of the listData Sheet is a must in the store. You need to describe your product for sure. More than that, are you prioritizing the descriptives?For instance, if your business is selling PCs in bulks to organizations, you are expected to put up the screen size and CPU specifications more than the mouse and keyboard.You must understand, figure out and present the data that is crucial to your sellers, which can be represented in datasheetsMoreover, you need to keep the description brief, yet detailed. An article here will help you with the same.Standard Certification and Easy Return policy for the productsB2B relies on trustworthiness. With standard certifications by your name, you can easily replace the existing vendors in the list.With your landing page showcasing the awards and the certificates, your branding is already a few levels up.Easy Return plays a key role in offering high-end customer experience. The option to return, reassures them for the quality of service offered and thus steering them to the next stage of the lead funnel. Here is one example of the same where the business owner is a SaaS provider and offers B2B services:The B2B owner presents the certifications they received on the landing page while they take charge of the product quality as wellA precise search engine saves time and trustA customer at B2C often scrolls for random products and is quite unpredictable with the choices. However, a customer at B2B is more focussed and understands his niche products better. Your Internal search engine should offer the customer highly refined searches with lesser possible inputs. The best-known eCommerce sites keep a track of the searches and repeat purchases in the past to make things more precise for specific buyers.B2B Progressive Web Apps to empower your mobile presenceMobile phones have certainly helped to boost B2B and B2C models at large. The involvement of a regular mobile phone in the business endeavour is credited to Progressive Web apps or PWA.The new-age application model combines the features offered by modern browsers along with the benefits of mobile experience. The parties can thus engage in a continuous loop on and off the systems.Final Thoughts On B2B Customer ExperienceIn a survey of about 10,000 US-based consumers, Tempkin Group once found that around 86 per cent of the users who received a great customer experience were more likely to resume. There are several more stats that advocate the importance of Customer Experience in recent times, across all the known business models. B2B is a highly focussed arena where the customer is specific to its needs. The Seller thus needs to come up with better efforts to channelise a highly delivering business. Above all, it is the way you approach and retain your customers, that matters the most. The demand for B2B services and competition are at an all-time high; differentiate yourself from the crowd and earn the right to ask for the place. Tags:#B2B#customer experience#Ecommerce business ideas Trends Driving the Loyalty Marketing Industry With This One Question, You’ll Never Need an Ic… Kunal Khullar Related Posts Kunal has 10+ years of experience in software services, development, and team management with diverse offshore software consulting firms in India and abroad. The Dos and Don’ts of Brand Awareness Videos AI is Not the Holy Grail of Sales, at Least Not…last_img read more